Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture

Emily Binversie, Lauren Baker, Corinne Engelman, Zhengling Hao, John Moran, Alexander Piazza, Susannah Sample & Peter Muir
Anterior cruciate ligament (ACL) rupture is an important condition of the human knee. Second ruptures are common and societal costs are substantial. Canine cranial cruciate ligament (CCL) rupture closely models the human disease. CCL rupture is common in the Labrador Retriever (5.79% prevalence), ~100-fold more prevalent than in humans. Labrador Retriever CCL rupture is a polygenic complex disease, based on genome-wide association study (GWAS) of single nucleotide polymorphism (SNP) markers. Dissection of genetic variation in...
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