Residual force enhancement is reduced in permeabilized fiber bundles from mdm muscles

Kiisa Nishikawa, Dhruv Mishra & Kiisa C Nishikawa
Residual force enhancement (RFE) is the increase in steady-state force after active stretch relative to the force after isometric contraction at the same final length. The mdm mutation in mice, characterized by a small deletion in N2A titin, has been proposed to prevent N2A titin-actin interactions so that active mdm muscles are more compliant than WT. This decrease in active muscle stiffness should be associated with reduced RFE. We investigated RFE in permeabilized soleus (SOL)...
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