Data from: Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

Gerco C. Hassink, Christian C. Raiss, M.J. Segers-Nolten, Richard J.A. Van Wezel, Vinod Subramaniam, Joost Le Feber, Mireille M.A.E. Claessens, M. M. A. E. Claessens, R. J. A. Van Wezel & I. M. J. Segers-Nolten
Amyloid aggregates of the protein α-synuclein (αS) called Lewy Bodies (LB) and Lewy Neurites (LN) are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. We have previously shown that high extracellular αS concentrations can be toxic to cells and that neurons take up αS. Here we aimed to get more insight into the toxicity mechanism associated with high extracellular αS concentrations (50-100 μM). High extracellular αS concentrations resulted in a reduction of the...
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