Data from: An MRI measure of degenerative and cerebrovascular pathology in Alzheimer’s disease

Adam M. Brickman, Giuseppe Tosto, Jose Gutierrez, Howard Andrews, Yian Gu, Atul Narkhede, Batool Rizvi, Vanessa Guzman, Jennifer J. Manly, Jean Paul Vonsattel, Nicole Schupf & Richard Mayeux
Objective: To develop, replicate, and validate an MRI-based quantitative measure of both cerebrovascular and neurodegeneration in Alzheimer’s disease for clinical and potentially research purposes. Methods. We used data from a cross-sectional and longitudinal community-based study of Medicare-eligible residents in northern Manhattan followed every 18-24 months (N=1,175, mean age=78 years). White matter hyperintensities, infarcts, hippocampal volumes, and cortical thicknesses were quantified from MRI and combined to generate an MRI measure associated with episodic memory. The combined...
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