Data from: High fat diet induces microbiota-dependent silencing of enteroendocrine cells

John Rawls, Lihua Ye, Olaf Mueller, Jennifer Bagwell, Michel Bagnat & Rodger Liddle
Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that sense and transduce nutrient information. Consumption of dietary fat contributes to metabolic disorders, but EEC adaptations to high fat feeding were unknown. Here, we established a new experimental system to directly investigate EEC activity in vivo using a zebrafish reporter of EEC calcium signaling. Our results reveal that high fat feeding alters EEC morphology and converts them into a nutrient insensitive state that...
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