In vivo transcriptome of Lactobacillus acidophilus and colonization impact on murine host intestinal gene expression

Yong Jun Goh, Rodolphe Barrangou & Todd Klaenhammer
Lactobacillus acidophilus NCFM is a probiotic strain commonly used in dairy products and dietary supplements. Post-genome in vitro studies of NCFM thus far have linked potential key genotypes to its probiotic-relevant attributes including gut survival, prebiotic utilization, host interactions and immunomodulatory activities. To corroborate and extend beyond previous in vivo and in vitro functional studies, we employed a dual RNA-seq transcriptomic approach to identify genes potentially driving the gut fitness and activities of L. acidophilus...
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