Data from: Dopamine promotes motor cortex plasticity and motor skill learning via PLC activation

Mengia-Seraina Rioult-Pedotti, Ana Pekanivic, Clement Osei Atiemo, John Marshall, Andreas Rüdiger Luft & Ana Pekanovic
Dopaminergic neurons in the ventral tegmental area, the major midbrain nucleus projecting to the motor cortex, play a key role in motor skill learning and motor cortex synaptic plasticity. Dopamine D1 and D2 receptor antagonists exert parallel effects in the motor system: they impair motor skill learning and reduce long-term potentiation. Traditionally, D1 and D2 receptor modulate adenylyl cyclase activity and cyclic adenosine monophosphate accumulation in opposite directions via different G-proteins and bidirectionally modulate protein...
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