Data from: A role of OCRL in clathrin-coated pit fission and uncoating revealed by studies of Lowe syndrome cells

Ramiro Nández, Daniel M. Balkin, Mirko Messa, Summer Paradise, Heather Czapla, Marco Y. Hein, Matthias Mann, Pietro De Camilli, James S Duncan & Liang Liang
Mutations in the inositol 5-phosphatase OCRL cause Lowe syndrome and Dent's disease. Although OCRL, a direct clathrin interactor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been primarily attributed to intracellular sorting defects. Here we show that OCRL loss in Lowe syndrome patient fibroblasts impacts clathrin-mediated endocytosis and results in an endocytic defect. These cells exhibit an accumulation of clathrin-coated vesicles and an increase in U-shaped clathrin-coated pits, which may result from sequestration of...
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