Data from: Assessment of dysmyelination with RAFFn MRI: application to murine MPS I

David Satzer, Christina DiBartolomeo, Michael M. Ritchie, Christine Storino, Timo Liimatainen, Hanne Hakkarainen, Djaudat Idiyatullin, Silvia Mangia, Shalom Michaeli, Ann M. Parr & Walter C. Low
Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice...
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