Data from: A single 17D Yellow Fever vaccination provides lifelong immunity; characterization of Yellow-Fever-specific neutralizing antibody and T-cell responses after vaccination

Rosanne W. Wieten, Emile F. F. Jonker, Ester M. M. Van Leeuwen, Ester B. M. Remmerswaal, Ineke J. M. Ten Berge, Adriëtte W. De Visser, Perry J. J. Van Genderen, Abraham Goorhuis, Leo G. Visser, Martin P. Grobusch & Godelieve J. De Bree
Introduction: Prompted by recent amendments of Yellow Fever (YF) vaccination guidelines from boost to single vaccination strategy and the paucity of clinical data to support this adjustment, we used the profile of the YF-specific CD8+ T-cell subset profiles after primary vaccination and neutralizing antibodies as a proxy for potentially longer lasting immunity. Methods and Findings: PBMCs and serum were collected in six individuals on days 0, 3, 5, 12, 28 and 180, and in 99...
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