Data from: TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

F. Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E. Deane & Louise H. Boyle
Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules, however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. Here, using immunopeptidomics in combination with novel cell-based assays that assess TAPBPR-mediate peptide exchange, we reveal a critical role for the K22-D35 loop of TAPBPR in mediating peptide exchange on MHC I. We identify a specific leucine within this loop that enables TAPBPR to facilitate...
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