Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

Yan-Qin Yu, Yulan Li, Lixuan Li, Jintao Wu, Zhenggang Zhu, Xiang Feng, Liming Qin, Yuwei Zhu, Zilong Qiu & Shumin Duan
Astrocytes respond to and regulate neuronal activity, yet their role in mammalian behavior remains incompletely understood. Especially unclear is whether, and if so how, astrocyte activity regulates contextual fear memory, the dysregulation of which leads to pathological fear-related disorders. We generated GFAP-ChR2-EYFP rats to allow the specific activation of astrocytes in vivo by optogenetics. We found that after memory acquisition within a temporal window, astrocyte activation disrupted memory consolidation and persistently decreased contextual but not...
1 citation reported since publication in 2020.
94 views reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?
22 downloads reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?