Data from: Generalized selection to overcome innate immunity selects for host breadth in an RNA virus

Brian R. Wasik, Andrés R. Muñoz-Rojas, Kenichi W. Okamoto, Kathryn Miller-Jensen & Paul E. Turner
Virus-host co-evolution has selected for generalized host defense against viruses, exemplified by interferon production/signaling and other innate immune function in eukaryotes such as humans. Although cell-surface binding primarily limits virus infection success, generalized adaptation to counteract innate immunity across disparate hosts may contribute to RNA virus emergence potential. We examined this idea using vesicular stomatitis virus (VSV) populations prevoously evolved on strictly immune deficient (HeLa) cells, strictly immune competent (MDCK) cells, or on alternating deficient/competent...
1 citation reported since publication in 2015.
69 views reported since publication in 2015.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?
4 downloads reported since publication in 2015.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?