Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults

Paul Kelly, Mubanga Chama, Beatrice Amadi, Kanta Chandwe, Ellen Besa, Kanekwa Zyambo, Phillip I. Tarr, Nurmohammad Shaikh, I Malick Ndao, Chad Storer & Richard Head
Background: Environmental enteropathy (EE) contributes to growth failure in millions of children worldwide, but its relationship to clinical malnutrition has not been elucidated. We used RNA sequencing to compare duodenal biopsies from adults and children with EE, and from children with severe acute malnutrition (SAM), to define key features of these malnutrition-related enteropathies. Methods: RNA was extracted and sequenced from biopsies of children with SAM in hospital (n=27), children with non-responsive stunting in the community...
1 citation reported since publication in 2021.
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