Data from: Levels of 8-oxodG predict hepatobiliary-pathology in Opisthorchis viverrini endemic settings in Thailand
Prasert Saichua, Anna Yakovleva, Christine Kamamia, Amar R. Jariwala, Jiraporn Sithithaworn, Banchop Sripa, Paul J. Brindley, Thewarach Laha, Eimorn Mairiang, Chawalit Pairojkul, Narong Khuntikeo, Jason P. Mulvenna, Paiboon Sithithaworn, Jeffrey Michael Bethony, Banchob Sripa & Jason Mulvenna
Opisthorchis viverrini is distinct among helminth infections as it drives a chronic inflammatory response in the intrahepatic bile duct that progresses from advanced periductal fibrosis (APF) to cholangiocarcinoma (CCA). Extensive research shows that oxidative stress (OS) plays a critical role in the transition from chronic O. viverrini infection to CCA. OS also results in the excision of a modified DNA lesion (8-oxodG) into urine, the levels of which can be detected by immunoassay. Herein, we...
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