Data from: Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis

Paul Riccio, Cristina Cebrian, Hui Zong, Simon Hippenmeyer & Frank Costantini
Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and is critical for normal nephron number, while low nephron number is implicated in hypertension and renal disease. Ureteric bud growth and branching requires GDNF signaling from the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase and coreceptor Gfrα1; Ret signaling up-regulates transcription factors Etv4 and Etv5, which are also critical for branching. Despite extensive...
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