Tolerance of novel toxins through generalized mechanisms: simulating gradual host shifts of butterflies

Emilie C. Snell-Rood, Kristin L Sikkink, Reilly Hostager, Megan E. Kobiela, Nathan Fremling, Katherine Johnston & Amod Zambre
Organisms encounter a wide range of toxic compounds in their environments, from chemicals that serve anti-consumption or anti-competition functions, to pollutants and pesticides. Although we understand many detoxification mechanisms that allow organisms to consume toxins typical of their diet, we know little about why organisms vary in their ability to tolerate entirely novel toxins. We tested whether variation in generalized stress responses, such as antioxidant pathways, may underlie variation in reactions to novel toxins, and,...
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