Parkinson’s disease propagation using MRI biomarkers and partial least squares path modeling

Nadya Pyatigorskaya, Lydia Yahia Cherif, Romain Valabregue, Rahul Gaurav, Fatma Gargouri, Claire Ewenczyk, Cecile Gallea, Sara Fernandez-Vidal, Isabelle Arnulf, Marie Vidailhet & Stephane Lehericy
Objectives: The classical Braak neuropathological staging model in Parkinson's disease (PD) suggests that brain lesions progress from the medulla oblongata to the cortex. An alternative model in which neurodegeneration first occurs in the cortex has also been proposed. These two models may correspond to different patient phenotypes. To test these two models and investigate if they were influenced by the presence of rapid eye movement sleep behavior disorder (RBD) we used multimodal MRI and Partial...
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