Modulation of fracture healing by the transient accumulation of senescent cells

Dominik Saul, David Monroe, Jennifer Rowsey, Robyn Kosinsky, Stephanie Vos, Madison Doolittle, Joshua Farr, Sundeep Khosla, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle & Joshua N Farr
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined. Here, we performed an in silico analysis of public mRNAseq data and found that senescence and senescence-associated secretory phenotype (SASP) markers increased during fracture healing. We next directly established that the expression of senescence biomarkers increased markedly during murine...
2 citations reported since publication in 2021.
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