Colorectal cancer scRNA-seq 10xG-format data matrix

Christopher Lausted, Raymond Yeung, Xiaowei Yan, Neda Jabbari, Qiang Tian, Heidi Kenerson, Changting Meng, Dani Bergey, Venu Pillarisetty, Kevin Sullivan, Priyanka Baloni & Leroy Hood
Metastatic colorectal cancer (CRC) is a major cause of cancer-related death and incidence is rising in the younger population (<50 years). Current chemotherapies can achieve response rates above 50%, but immunotherapies have limited value for patients with microsatellite-stable (MSS) cancers. The present study investigates the impact of chemotherapy on the tumor immune microenvironment. We treat human liver metastases slices with 5-Fluorouracil (5FU) plus either irinotecan or oxaliplatin, then perform single-cell transcriptome analyses. Results from eight...
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