Data from: Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics

Martijn F. Schenk, Sariette Witte, Merijn L. M. Salverda, Bertha Koopmanschap, Joachim Krug & J. Arjan G. M. De Visser
Pleiotropy is a key feature of the genotype–phenotype map, and its form and extent have many evolutionary implications, including for the dynamics of adaptation and the evolution of specialization. Similarly, pleiotropic effects of antibiotic resistance mutations may affect the evolution of antibiotic resistance in the simultaneous or fluctuating presence of different antibiotics. Here, we study the role of pleiotropy during the in vitro adaptation of the enzyme TEM-1 β-lactamase to two novel antibiotics, cefotaxime (CTX)...
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