Data from: Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

Florian Baier, Nansook Hong, Gloria Yang, Anna Pabis, Charlotte M. Miton, Alexandre Barrozo, Paul D. Carr, Shina C. L. Kamerlin, Colin J. Jackson & Nobuhiko Tokuriki
Genetic variation among orthologous proteins can cause cryptic phenotypic properties that only manifest in changing environments. Such variation may impact the evolvability of proteins, but the underlying molecular basis remains unclear. Here, we performed comparative directed evolution of four orthologous metallo-β-lactamases toward a new function and found that different starting genotypes evolved to distinct evolutionary outcomes. Despite a low initial fitness, one ortholog reached a significantly higher fitness plateau than its counterparts, via increasing catalytic...
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These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
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