Data from: Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution

Jonathan Okerblom, William Fletes, Hemal H. Patel, Simon Schenk, Ajit Varki & Ellen C. Breen
Compared to other primates, humans are exceptional long-distance runners, a feature that emerged in genus Homo ~2 million years ago (mya) and is classically attributed to anatomical and physiological adaptations such as an enlarged gluteus maximus and improved heat dissipation. However, no underlying genetic changes have currently been defined. Two-three mya, an exon deletion in the CMP-Neu5Ac Hydroxylase (CMAH) gene also became fixed in our ancestral lineage. Cmah loss in mice exacerbates disease severity in...
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