Intracellular sodium elevation reprograms cardiac metabolism: Metabolomics data

Dunja Aksentijevic, Anja Karlstaedt, Marina Basalay, Brett O'Brien, David Sanchez-Tatay, Seda Eminaga, Alpesh Thakker, Daniel Tennant, William Fuller, Thomas Eykyn, Heinrich Taegtmeyer & Michael Shattock
Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodeling occurs. We assessed whether acute (75μM ouabain 100nM blebbistatin) and chronic myocardial Naiload (PLM3SA mouse) are causally linked to metabolic remodeling and whether the hypertrophied failing heart shares a common Na-mediated metabolic ‘fingerprint’. Control (PLMWT), transgenic (PLM3SA), ouabain treated and hypertrophied Langendorff-perfused mouse hearts were studied by 23Na, 31P, 13C NMR followed by 1H NMR metabolomic profiling....
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