Data from: Progression of neuronal damage in an in vitro model of the ischemic penumbra

Joost Le Feber, Stelina Tzafi Pavlidou, Niels Erkamp, Michel J. A. M. Van Putten & Jeannette Hofmeijer
Improvement of neuronal recovery in the ischemic penumbra around a brain infarct has a large potential to advance clinical recovery of patients with acute ischemic stroke. However, pathophysiological mechanisms leading to either recovery or secondary damage in the penumbra are not completely understood. We studied neuronal dynamics in a model system of the penumbra consisting of networks of cultured cortical neurons exposed to controlled levels and durations of hypoxia. Short periods of hypoxia (pO2≈20mmHg) reduced...
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