Data from: The N-end Rule Pathway and Ubr1 enforce protein compartmentalization via P2-encoded cellular location signals

Anthony Tran
The Arg/N-end Rule Pathway and Ubr1, an E3 ligase conserved from yeast to humans, is involved in the degradation of misfolded proteins in the cytosol. However, the root physiological purpose of this activity is not completely understood. Through a systematic examination of single residue P2-position mutants of misfolded proteins, and global and targeted bioinformatic analyses of the yeast proteome, we determined that Ubr1 preferentially targets mistranslocated secretory and mitochondrial proteins in the cytosol. Degradation by...
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