Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

Anna Bowen, Jane Chen, Y. Waterlily Huang, Nathan Baertsch, Sekun Park & Richard Palmiter
Parabrachial CGRP neurons receive diverse threat-related signals and contribute to multiple phases of adaptive threat responses in mice, with their inactivation attenuating both unconditioned behavioral responses to somatic pain and fear-memory formation. Because CGRPPBN neurons respond broadly to multi-modal threats, it remains unknown how these distinct adaptive processes are individually engaged. We show that while three partially separable subsets of CGRPPBN neurons broadly collateralize to their respective downstream partners, individual projections accomplish distinct functions: hypothalamic...
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