Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion

Jeffrey D. Zaremba, Anastasia Diamantopoulou, Nathan B. Danielson, Andres D. Grosmark, Patrick W. Kaifosh, Jack C. Bowler, Zhenrui Liao, Fraser T. Sparks, Joseph A. Gogos & Attila Losonczy
Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-related role of place cell dynamics in health and disease remains elusive. Using chronic two-photon Ca2+ imaging in hippocampal area CA1 of wild-type and Df(16)A+/− mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction...
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