Single-cell phenotypic characteristics of tolerance under recurring antibiotic exposure in Escherichia coli

Silvia Kollerová, Lionel Jouvet, Julia Smelková, Sara Zunk-Parras, Alexandro Rodriguez-Rojas & Ulrich Steiner
Non-heritable drug resistance, such as tolerance and persistence towards antibiotics, is little characterized compared to genetic resistance. Tolerance and persistence allow cells to survive application of antibiotics that are bactericidal to non-tolerant cells. Non-heritable drug resistance challenges antibiotic treatment, particularly of recurrent infections, and have implications towards heritable resistance evolution. Tolerant cells have commonly been characterized as growth arrested cells prior and during antibiotic application that quickly resume growth post-application. Here, we explore characteristic of...
1 citation reported since publication in 2022.
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