Data from: Robust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information

Sergey Ovchinnikov, Hetunandan Kamisetty & David Baker
Do the amino acid sequence identities of residues that make contact across protein interfaces covary during evolution? If so, such covariance could be used to predict contacts across interfaces and assemble models of biological complexes. We find that residue pairs identified using a pseudo-likelihood based method to covary across protein-protein interfaces in the 50S ribosomal unit and 28 additional bacterial protein complexes with known structure are almost always in contact in the complex provided that...
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