Data from: Deleterious mutations show increasing negative effects with age in Drosophila melanogaster

Martin Brengdahl, Christopher M. Kimber, Phoebe Elias, Josephine Thompson & Urban Friberg
Background In order for ageing to evolve in response to a declining strength of selection with age, a genetic architecture that allows for mutations with age-specific effects on organismal performance is required. Our understanding of how selective effects of individual mutations are distributed across ages is however poor. Established evolutionary theories assume that mutations causing ageing have negative late-life effects, coupled to either positive or neutral effects early in life. New theory now suggests evolution...
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