Data from: How does epistasis influence the response to selection?

Nicholas H. Barton
Much of quantitative genetics is based on the "infinitesimal model", under which selection has a negligible effect on the genetic variance. This is typically justified by assuming a very large number of loci with additive effects. However, it applies even when genes interact, provided that the number of loci is large enough that selection on each of them is weak relative to random drift. In the long term, directional selection will change allele frequencies, but...
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