Data from: Functional and mechanistic neurotoxicity profiling using human iPSC–derived neural 3D cultures

Oksana Sirenko, Frederick Parham, Kristen Ryan, Carole Crittenden, Grischa Chandy, Sarah Vargas-Hurlston, Steven Dea, Neha Sodhi, Steven Biesmans, Sergio Mora, Olivin Guicherit, Mamta Behl, Fabian Zanella, Ryan Gordon & Cassiano Carromeu
Neurological disorders affect millions of people worldwide and appear to be on the rise. While the reason for this increase remains unknown, environmental factors are a suspected contributor. Hence, there is an urgent need to develop more complex, biologically relevant, and predictive in vitro assays to screen larger sets of compounds with the potential for neurotoxicity. Here, we employed a human induced pluripotent stem cell (iPSC)-based 3D neural platform composed of mature cortical neurons and...
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