Data from: NMDA receptor antagonists and pain relief: a meta-analysis of experimental trials

Trevor Thompson, Fiona Whiter, Katy Gallop, Nicola Veronese, Marco Solmi, Paul Newton & Brendon Stubbs
OBJECTIVES: We conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of N-methyl-D-aspartate receptor (NMDAR) antagonists. METHODS: Six major databases were systematically searched (to 03/2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis. RESULTS: Searches identified 70 eligible trials (N=1069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease...
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