Data from: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

Shabnam Mohammadi, Santiago Herrera-Álvarez, Lu Yang, María Del Pilar Rodríguez-Ordoñez, Karen Zhang, Jay F. Storz, Susanne Dobler, Andrew J. Crawford & Peter Andolfatto
A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the recurrent evolution of resistance to cardiotonic steroids (CTS) across tetrapods, which occurs via specific amino acid substitutions to the α-subunit family of Na,K-ATPases (ATP1A). After identifying a series of recurrent...
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