Isolating human monoclonal antibodies against adeno-associated virus from donors with pre-existing immunity

James Wilson, April R. Giles, Roberto Calcedo & Anna P. Tretiakova
With the advent of single B-cell cloning technology, we can isolate antibodies against virtually any antigen to study the interaction of a given pathogen with the immune system and develop novel therapeutic strategies. Antibodies directed against the capsid of adeno-associated viruses (AAV) are a significant obstacle to effectively leveraging AAV as a gene-delivery vector in seropositive individuals. In order to design next-generation vectors that can evade neutralization by these antibodies, studies have mapped the epitopes...
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