Data from: Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

Christine J. Huh, Bo Zhang, Matheus Victor, Sonika Dahiya, Luis F. Z. Batista, Steve Horvath, Andrew S. Yoo, Matheus B Victor & Luis FZ Batista
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neurons that maintain multiple age-associated signatures. Application of an epigenetic biomarker of aging (referred...
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