Education is associated with Aβ burden in preclinical familial and sporadic Alzheimer’s disease

Julie Gonneaud, Christophe Bedetti, Alexa Pichet Binette, Tammie Benzinger, John Morris, Randall Bateman, Judes Poirier, John Breitner & Sylvia Villeneuve
Objective. To determine whether years of education and the ε4 risk allele at APOE influence β-amyloid pathology similarly in asymptomatic individuals with a family history of sporadic Alzheimer’s disease (AD) and pre-symptomatic autosomal dominant AD mutation carriers. Methods. We analyzed cross-sectional data from 106 asymptomatic individuals with a parental history of sporadic AD (PREVENT-AD cohort; age=67.28±4.72 years) and 117 pre-symptomatic autosomal dominant AD mutation carriers (DIAN cohort; age=34.00±9.43 years). All participants underwent structural MRI and...
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