A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau

Dongming Xu
Similar highland phenotypes have evolved in different endemic mammals in the Qinghai-Tibetan Plateau (QTP). However, until' now, we know little about genomic underpinnings of these convergent phenotypes. Here, we de novo sequenced genomes of plateau pika and plateau zokor. Along with yak and Tibetan antelope genomes, we discovered that all four QTP mammal species share a mutation Q247R in RETSAT. In vitro functional experiments indicate that this mutation significantly increases RETSAT enzymatic activity. Knock-in mice...
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These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?