Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

Grazyna Jasienska, Peter T. Ellison, Andrzej Galbarczyk, Michal Jasienski, Malgorzata Kalemba-Drozdz, Maria Kapiszewska, Ilona Nenko, Inger Thune & Anna Ziomkiewicz
The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major...
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