Data from: Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon

Benjamin A. Gilston, Suning Wang, Mason D. Marcus, Mónica A. Canalizo-Hernández, Elden P. Swindell, Yi Xue, Alfonso Mondragón & Thomas V. O'Halloran
Commensal microbes, whether they are beneficial or pathogenic, are sensitive to host processes that starve or swamp the prokaryote with large fluctuations in local zinc concentration. To understand how microorganisms coordinate a dynamic response to changes in zinc availability at the molecular level, we evaluated the molecular mechanism of the zinc-sensing zinc uptake regulator (Zur) protein at each of the known Zur-regulated genes in Escherichia coli. We solved the structure of zinc-loaded Zur bound to...
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