Data from: Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

Alexander Borodavka, Eric C. Dykeman, Waldemar Schrimpf & Don C. Lamb
Segmented RNA viruses are ubiquitous pathogens, which include influenza viruses and rotaviruses. A major challenge in understanding their assembly is the combinatorial problem of a non-random selection of a full genomic set of distinct RNAs. This process involves complex RNA-RNA and protein-RNA interactions, which are often obscured by non-specific binding at concentrations approaching in vivo assembly conditions. Here, we present direct experimental evidence of sequence-specific inter-segment interactions between rotavirus RNAs, taking place in a complex...
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