A randomized clinical trial to compare P. falciparum gametocytaemia and infectivity following blood-stage or mosquito bite induced controlled malaria infection

Teun Bousema, Manon Alkema, Isaie Reuling, Gerdie De Jong, Kjerstin Lanke, Luc Coffeng, Geert-Jan Van Gemert, Marga Van De Vegte-Bolmer, Quirijn De Mast, Reinout Van Crevel, Christian Ockenhouse, Karen Ivinson, James McCarthy, Robert Sauerwein & Katharine Collins
For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and to develop models to allow early clinical evaluation of transmission-blocking interventions. We previously described a Controlled Human Malaria Infection protocol for induction of gametocytemia in malaria naïve volunteers by mosquito bite (CHMI-trans) (Reuling et al., 2018). Here, we compared gametocyte production and infectivity in the CHMI-trans model after bites of Plasmodium falciparum (Pf)- infected mosquitoes to that after intravenous administration...
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