Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

Abigail E Bryson, Emily R Lanier, Kin H Lau, John P Hamilton, Brieanne Vaillancourt, Davis Mathieu, Alan E Yocca, Garret P Miller, Patrick P Edger, C Robin Buell & Bjoern Hamberger
The spatial organization of genes within plant genomes can drive evolution of specialized metabolic pathways. In this study we investigated the origin and subsequent evolution of a diterpenoid biosynthetic gene cluster (BGC) present throughout the Lamiaceae (mint) family. Terpenoids are important specialized metabolites in plants with diverse adaptive functions that enable environmental interactions, such as chemical defense. Based on core genes found in the BGCs of all species examined across the Lamiaceae, we predict a...
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