RNAseq data from: A novel TNFR2 agonist antibody expands highly potent regulatory T cells

Willem Kuhtreiber
Patients suffering from inflammatory diseases may benefit by enhancing the function of immunosuppressive regulatory T cells (Tregs). Tumor necrosis factor receptor 2 (TNFR2) has emerged as a central control switch on Tregs for maintaining and restoring the immune balance. Here, we characterized a new human TNFR2-directed antibody agonist. We found that the antibody agonist expands Tregs with a cellular phenotype and mechanistic properties of maximally suppressive Tregs. RNA-sequencing and metabolite data showed that the antibody...
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5 downloads reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?