The transcription factor network of E. coli steers global responses to shifts in RNAP concentration

Bilena L.B. Almeida, Mohamed N.M. Bahrudeen, Vatsala Chauhan, Suchintak Dash, Vinodh Kandavalli, Antti Häkkinen, Jason Lloyd-Price, Cristina S.D. Palma, Ines S.C. Baptista, Abhishekh Gupta, Juha Kesseli, Eric Dufour, Olli-Pekka Smolander, Matti Nykter, Petri Auvinen, Howard T. Jacobs, Samuel M.D. Oliveira & Andre S. Ribeiro
The robustness and sensitivity of gene networks to environmental changes is critical for cell survival. How gene networks produce specific, chronologically ordered responses to genome-wide perturbations, while robustly maintaining homeostasis, remains an open question. We analysed if short- and mid-term genome-wide responses to shifts in RNA polymerase (RNAP) concentration are influenced by the known topology and logic of the transcription factor network (TFN) of Escherichia coli. We found that, at the gene cohort level, the...
1 citation reported since publication in 2021.
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