Antibody features towards VAR2CSA and CSA binding infected erythrocytes in a cohort of pregnant women from PNG

Elizabeth Aitken, Amaya Ortega-Pajares, Agersew Alemu, Wina Hasang, Saber Dini, Holger Unger, Maria Ome-Kaius, Morten Nielsen, Ali Salanti, Joe Smith, Stephen Kent, P Mark Hogarth, Bruce Wines, Julie Simpson, Timon Damelang, Amy Chung & Stephen Rogerson
Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum infected erythrocytes that express the parasite protein VAR2CSA on their surface can bind to placental chondroitin sulfate-A. It has been hypothesized that naturally acquired antibodies towards VAR2CSA protect against placental infection, but it has proven difficult to use measures of antibody to identify individuals protected from disease. We used a systems serology approach to identify naturally acquired antibody features...
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