Gene drives for vertebrate pest control: realistic spatial modelling of eradication probabilities and times for island mouse populations

Aysegul Birand, Aysegul Birand, Phillip Cassey, Joshua Ross, James Russell, Paul Thomas & Thomas Prowse
Invasive alien species continue to threaten global biodiversity. CRISPR-based gene drives, which can theoretically spread through populations despite imparting a fitness cost, could be used to suppress or eradicate pest populations. We develop an individual-based, spatially explicit, stochastic model to simulate the ability of CRISPR-based homing and X-chromosome shredding drives to eradicate populations of invasive mice (Mus muculus) from islands. Using the model, we explore the interactive effect of the efficiency of the drive constructs...
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