Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene

Achim P. Popp, Johannes Hettich & J. Christof M. Gebhardt
Transcription is a vital process activated by transcription factor (TF) binding. The active gene releases a burst of transcripts before turning inactive again. While the basic course of transcription is well understood, it is unclear how binding of a TF affects the frequency, duration and size of a transcriptional burst. We systematically varied the residence time and concentration of a synthetic TF and characterized the transcription of a synthetic reporter gene by combining single molecule...
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