Intracranial haemodynamic relationships in patients with cerebral small vessel disease

Gordon Blair, Michael Thrippleton, Yulu Shi, Iona Hamilton, Michael Stringer, Francesca Chappell, David Alexander Dickie, Peter Andrews, Ian Marshall, Fergus Doubal & Joanna Wardlaw
Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and cerebrospinal fluid (CSF) pulsatility, and their independent relationship to cerebral small vessel disease (SVD) features, in patients with minor ischaemic stroke and MRI evidence of SVD. Methods We recruited patients with minor ischaemic stroke and assessed CVR using Blood Oxygen Level Dependent (BOLD) MRI during a hypercapnic challenge, cerebral blood flow, vascular and CSF pulsatility using phase contrast MRI, and structural MR brain imaging to...
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